This was done via a Grignard reaction.
Saturated NaCl solution Methods: Before beginning the experiment, wrap the glassware involved in aluminum foil and place the glassware in an oven to ensure that the glassware is dry and free of water. Obtain the glassware from the oven and unwrap the aluminum foil. Get one needle and three 1.
One syringe will be used for bromobenzene, one for methyl benzoate, and one for adding diethyl ether to the reaction. The syringe used to add diethyl ether to the reaction will be used throughout the experiment.
Formation of phenyl magnesium bromide: Assemble the microscale apparatus to be used during the preparation of phenyl magnesium bromide. Before proceeding to the next step, remember to quickly recap all of the reagents used in the experiment to ensure that there is no contamination from water vapor.
Into vial 1, place 2. Gently shake the mixture. Into vial 2, place 1. Place into a 10 mL round-bottom flask equipped with a spin vane, 2.
Using one of the 1. Continue refluxing for an additional 3 minutes. Transfer the remaining contents of vial 1 into the round bottom flask over a minute period. Continue refluxing for approximately minutes or until nearly all of the magnesium reacts and the solution turns a clear amber color.
Formation of triphenylmethanol-the product: Continue refluxing during the 2-minute period.
Reflux the solution for an additional 30 minutes. While keeping the round-bottom flask capped and sealed, allow the solution to cool to room temperature using an ice water bath. Use a small beaker for the ice water bath and place the round-bottom flask inside the beaker so that it can be cooled.
Into the round-bottom flask, add 20 drops of distilled H2O dropwise. Begin swirling the solution. Continuing swirling, add drops of a 3M HCl solution to the reaction.
If necessary, add more diethyl ether to the solution. Observe the evolution of the H2 gas during the reaction and then remove the reaction mixture from the ice water bath.
Disassemble the microscale apparatus. Observe the biphasic clear mixture of organic diethyl ether layer at the top and the acidic aqueous layer at the bottom of the reaction mixture.
Isolation and characterization of the product-Triphenylmethanol via extraction: Using a clean filter-tip pipette, transfer the biphasic mixture from the round-bottom flask to a clean, dry 5 mL conical vial.
Rinse the round-bottom flask with a small amount of diethyl ether.The benzaldehyde, benzophenone, and methyl benzoate reacted in with the phenylmagnesium bromide to form the Grignard products, benzhydrol and triphenylmethanol as displayed in the physical recovery of the products and the H NMR spectra.
Grignard Chemistry: Synthesis of Triphenylmethanol Write the mechanism of the reaction. Two equivalents of Grignard methoxide, is expelled. The second part is a carbonyl addition. (4) Write the reaction of your Grignard reagent, PhMgBr, with water.
This is what will happen if your flask is. Nov 11, · This organic chemistry video tutorial discusses the synthesis reaction mechanism of grignard reagents with water - H2O, D2O, aldehyes including .
Reaction of Methylmagnesium Iodide with Benzonitrile in Diethyl Ether Reaction of Methylmagnesium Iodide with Benzophenone in Diethyl Ether Reaction of Phenylmagnesium Iodide with Benzophenone in Diethyl Ether Reaction of Phenylmagnesium Bromide with Benzophenone in Diethyl Ether Method of making a Kinetic Run and Subsequent Analysis III.
Some biphenyl can form if not all of the phenyl bromide has already reacted with magnesium solid to form the Grignard reagent. In that situation, the Grignard reagent acts as a very strong nucleophile towards the regular phenyl bromide. General reaction mechanism for the Grignard reaction.
The mechanism is depicted in Figure 1. As pictured previously, the first part of will be adding your Grignard reagent to benzophenone to form triphenylmethanol. Br Bromobenzene bp oC M.W. density g/mL Magnesium At.W. Phenylmagnesium bromide an intermediate but not.